| 11/13/05 | vs. | NC Greensboro | 71-48 |
| 11/14/05 | at | Washington | 54-87 |
| 11/15/05 | vs. | Miami FL | 54-80 |
| 11/21/05 | at | Central Michigan | 62-67 |
| 11/29/05 | hosting | North Dakota St. | 60-55 |
| 12/03/05 | at | Illinois St. | 51-59 |
| 12/07/05 | at | Wisconsin | 62-82 |
| 12/10/05 | hosting | Montana St. | 75-73 |
| 12/14/05 | hosting | Eastern Michigan | 73-69 |
| 12/17/05 | at | Wisconsin Milwaukee | 60-80 |
| 12/21/05 | hosting | Michigan St. | 69-98 |
| 12/29/05 | hosting | Northern Michigan | 106-58 |
| 12/30/05 | hosting | UC Irvine | 77-65 |
| 01/02/06 | at | Detroit | 57-60 OT |
| 01/05/06 | at | Youngstown St. | 70-95 |
| 01/11/06 | hosting | Illinois Chicago | 90-84 OT |
| 01/14/06 | hosting | Wisconsin Milwaukee | 84-77 |
| 01/19/06 | hosting | Wright St. | 57-44 |
| 01/21/06 | hosting | Cleveland St. | 63-66 |
| 01/26/06 | at | Loyola Chicago | 72-66 |
| 01/28/06 | at | Illinois Chicago | 68-81 |
| 01/30/06 | hosting | Detroit | 45-42 |
| 02/02/06 | at | Butler | 66-72 OT |
| 02/04/06 | at | Wright St. | 49-59 |
| 02/08/06 | hosting | Loyola Chicago | 69-59 |
| 02/11/06 | hosting | Youngstown St. | 80-58 |
| 02/13/06 | hosting | Butler | 57-63 |
| 02/18/06 | hosting | Fairleigh Dickinson | 64-68 |
| 02/25/06 | at | Cleveland St. | 76-72 |
| 03/03/06 | vs. | Illinois Chicago | 76-66 |
| 03/04/06 | vs. | Butler | 51-73 |