| 09/03/05 | hosting | Southern Virginia | 41-7 |
| 09/10/05 | at | Austin Peay | 15-24 |
| 09/24/05 | hosting | Virginia-Wise | 34-22 |
| 10/01/05 | at | Shorter | 20-40 |
| 10/08/05 | hosting | Pikeville | 20-23 |
| 10/15/05 | at | Lambuth | 24-27 |
| 10/22/05 | at | Campbellsville | 60-62 |
| 10/29/05 | hosting | Kentucky Wesleyan | 22-32 |
| 11/05/05 | at | Bethel TN | 13-61 |
| 11/12/05 | hosting | Belhaven | 12-58 |