| 09/01/05 | at | West Alabama | 0-37 |
| 09/08/05 | at | Tennessee Tech | 10-52 |
| 09/17/05 | hosting | Missouri Valley | 12-32 |
| 09/24/05 | at | Shorter | 20-52 |
| 10/01/05 | hosting | Virginia-Wise | 25-21 |
| 10/08/05 | at | Union KY | 36-29 |
| 10/15/05 | hosting | Cumberland TN | 27-24 |
| 10/22/05 | hosting | Belhaven | 35-18 |
| 10/29/05 | at | Bethel TN | 13-31 |
| 11/05/05 | hosting | Campbellsville | 14-20 |
| 11/12/05 | at | Kentucky Wesleyan | 27-23 |