| 09/03/05 | hosting | Waynesburg | 21-17 |
| 09/10/05 | at | Case Western Reserve | 6-20 |
| 09/24/05 | hosting | Gettysburg | 49-21 |
| 10/01/05 | at | Wittenberg | 6-31 |
| 10/08/05 | hosting | Hiram | 53-6 |
| 10/15/05 | at | Ohio Wesleyan | 28-34 |
| 10/22/05 | hosting | Earlham | 38-7 |
| 10/29/05 | hosting | Oberlin | 32-26 |
| 11/05/05 | at | Wabash | 0-52 |
| 11/12/05 | at | Kenyon | 42-45 |