| 09/02/06 | at | Texas Tech | 3-35 |
| 09/09/06 | at | North Texas | 6-24 |
| 09/16/06 | hosting | Sam Houston St | 45-14 |
| 09/23/06 | hosting | Arkansas St | 55-9 |
| 09/30/06 | at | Tulane | 33-28 |
| 10/07/06 | at | UTEP | 21-24 |
| 10/14/06 | hosting | Marshall | 31-21 |
| 10/21/06 | at | East Carolina | 21-38 |
| 10/31/06 | hosting | Alabama-Birmingham | 22-9 |
| 11/11/06 | hosting | Houston | 27-37 |
| 11/18/06 | hosting | Tulsa | 34-24 |
| 11/25/06 | at | Rice | 27-31 |