| 04/02/07 | hosting | Boston | 7-1 |
| 04/04/07 | hosting | Boston | 1-7 |
| 04/05/07 | hosting | Boston | 1-4 |
| 04/06/07 | hosting | Detroit | 3-1 |
| 04/07/07 | hosting | Detroit | 5-6 |
| 04/08/07 | hosting | Detroit | 2-3 |
| 04/09/07 | at | Toronto | 1-9 |
| 04/10/07 | at | Toronto | 6-3 |
| 04/11/07 | at | Toronto | 4-7 |
| 04/12/07 | at | Baltimore | 1-2 OT |
| 04/13/07 | at | Baltimore | 1-8 |
| 04/14/07 | at | Baltimore | 4-6 |
| 04/16/07 | at | Detroit | 5-12 |
| 04/17/07 | at | Detroit | 6-7 |
| 04/18/07 | at | Detroit | 4-3 OT |
| 04/20/07 | hosting | Minnesota | 11-7 |
| 04/21/07 | hosting | Minnesota | 5-7 |
| 04/22/07 | hosting | Minnesota | 3-1 |
| 04/23/07 | hosting | Chi White Sox | 4-7 |
| 04/24/07 | hosting | Chi White Sox | 7-9 |
| 04/25/07 | at | Minnesota | 4-3 |
| 04/26/07 | at | Minnesota | 0-1 2OT |
| 04/27/07 | at | Seattle | 4-7 |
| 04/28/07 | at | Seattle | 8-3 |
| 04/29/07 | at | Seattle | 1-5 |
| 04/30/07 | hosting | Angels of Anaheim | 1-3 |
| 05/01/07 | hosting | Angels of Anaheim | 5-7 |
| 05/02/07 | hosting | Angels of Anaheim | 3-1 |
| 05/03/07 | hosting | Angels of Anaheim | 5-2 |
| 05/04/07 | hosting | Detroit | 3-6 |
| 05/05/07 | hosting | Detroit | 5-7 |
| 05/06/07 | hosting | Detroit | 4-13 |
| 05/08/07 | hosting | Oakland | 1-6 |
| 05/09/07 | hosting | Oakland | 3-2 |
| 05/10/07 | hosting | Oakland | 3-17 |
| 05/11/07 | at | Chi White Sox | 1-2 |
| 05/12/07 | at | Chi White Sox | 4-5 OT |
| 05/13/07 | at | Chi White Sox | 11-1 |
| 05/14/07 | at | Oakland | 2-1 |
| 05/15/07 | at | Oakland | 4-5 2OT |
| 05/16/07 | at | Oakland | 4-3 |
| 05/17/07 | at | Oakland | 7-4 |
| 05/18/07 | at | Colorado | 5-2 |
| 05/19/07 | at | Colorado | 4-6 |
| 05/20/07 | at | Colorado | 10-5 3OT |
| 05/22/07 | hosting | Cleveland | 4-3 |
| 05/23/07 | hosting | Cleveland | 11-7 |
| 05/24/07 | hosting | Cleveland | 3-10 |
| 05/25/07 | hosting | Seattle | 2-10 |
| 05/26/07 | hosting | Seattle | 1-9 |
| 05/27/07 | hosting | Seattle | 4-7 |
| 05/28/07 | hosting | Baltimore | 1-9 |
| 05/29/07 | hosting | Baltimore | 2-6 |
| 05/30/07 | hosting | Baltimore | 0-3 |
| 06/01/07 | at | Tampa Bay | 4-1 |
| 06/02/07 | at | Tampa Bay | 9-4 |
| 06/03/07 | at | Tampa Bay | 1-5 |
| 06/04/07 | at | Tampa Bay | 2-4 |
| 06/05/07 | at | Cleveland | 0-1 |
| 06/06/07 | at | Cleveland | 4-3 |
| 06/07/07 | at | Cleveland | 3-8 |
| 06/08/07 | hosting | Philadelphia | 8-4 |
| 06/09/07 | hosting | Philadelphia | 0-4 |
| 06/10/07 | hosting | Philadelphia | 17-5 |
| 06/12/07 | hosting | St. Louis | 8-1 |
| 06/13/07 | hosting | St. Louis | 3-7 |
| 06/14/07 | hosting | St. Louis | 17-8 |
| 06/15/07 | hosting | Florida | 6-2 |
| 06/16/07 | hosting | Florida | 8-9 |
| 06/17/07 | hosting | Florida | 5-4 |
| 06/18/07 | at | St. Louis | 5-3 |
| 06/19/07 | at | St. Louis | 1-5 |
| 06/20/07 | at | St. Louis | 6-7 5OT |
| 06/22/07 | at | Milwaukee | 6-11 |
| 06/23/07 | at | Milwaukee | 1-7 |
| 06/24/07 | at | Milwaukee | 4-3 2OT |
| 06/25/07 | at | Angels of Anaheim | 5-3 |
| 06/26/07 | at | Angels of Anaheim | 12-4 |
| 06/27/07 | at | Angels of Anaheim | 1-0 |
| 06/29/07 | hosting | Chi White Sox | 8-1 |
| 06/30/07 | hosting | Chi White Sox | 1-3 OT |
| 07/01/07 | hosting | Chi White Sox | 1-3 |
| 07/02/07 | hosting | Seattle | 3-2 2OT |
| 07/03/07 | hosting | Seattle | 17-3 |
| 07/04/07 | hosting | Seattle | 0-4 |
| 07/06/07 | hosting | Tampa Bay | 5-6 |
| 07/07/07 | hosting | Tampa Bay | 8-7 |
| 07/08/07 | hosting | Tampa Bay | 12-4 |
| 07/13/07 | at | Cleveland | 4-5 |
| 07/14/07 | at | Cleveland | 6-5 |
| 07/15/07 | at | Cleveland | 3-5 |
| 07/16/07 | at | Boston | 0-4 |
| 07/17/07 | at | Boston | 9-3 |
| 07/18/07 | at | Boston | 6-5 |
| 07/20/07 | at | Detroit | 10-2 |
| 07/21/07 | at | Detroit | 8-10 OT |
| 07/22/07 | at | Detroit | 5-2 |
| 07/23/07 | hosting | NY Yankees | 2-9 |
| 07/24/07 | hosting | NY Yankees | 4-9 |
| 07/25/07 | hosting | NY Yankees | 1-7 |
| 07/26/07 | hosting | NY Yankees | 7-0 |
| 07/27/07 | hosting | Texas | 6-1 |
| 07/28/07 | hosting | Texas | 6-5 |
| 07/29/07 | hosting | Texas | 10-0 |
| 07/30/07 | at | Minnesota | 1-3 |
| 07/31/07 | at | Minnesota | 3-5 |
| 08/01/07 | at | Minnesota | 5-3 OT |
| 08/03/07 | at | NY Yankees | 1-7 |
| 08/04/07 | at | NY Yankees | 8-16 |
| 08/05/07 | at | NY Yankees | 5-8 |
| 08/07/07 | hosting | Minnesota | 5-1 |
| 08/08/07 | hosting | Minnesota | 4-11 |
| 08/09/07 | hosting | Minnesota | 1-0 |
| 08/10/07 | hosting | Toronto | 1-2 |
| 08/11/07 | hosting | Toronto | 4-1 |
| 08/12/07 | hosting | Toronto | 1-4 |
| 08/13/07 | hosting | Toronto | 6-2 |
| 08/14/07 | at | Texas | 3-5 |
| 08/15/07 | at | Texas | 3-4 |
| 08/16/07 | at | Texas | 6-2 |
| 08/17/07 | at | Oakland | 9-2 |
| 08/18/07 | at | Oakland | 7-3 |
| 08/19/07 | at | Oakland | 1-6 |
| 08/20/07 | at | Chi White Sox | 3-4 |
| 08/21/07 | at | Chi White Sox | 2-5 |
| 08/22/07 | at | Chi White Sox | 7-6 |
| 08/24/07 | hosting | Cleveland | 2-1 |
| 08/25/07 | hosting | Cleveland | 4-9 |
| 08/26/07 | hosting | Cleveland | 3-5 2OT |
| 08/28/07 | hosting | Detroit | 6-3 |
| 08/29/07 | hosting | Detroit | 5-0 |
| 08/30/07 | hosting | Detroit | 1-6 |
| 08/31/07 | at | Minnesota | 9-4 |
| 08/31/07 | at | Minnesota | 0-5 |
| 09/01/07 | at | Minnesota | 4-6 |
| 09/02/07 | at | Minnesota | 8-1 |
| 09/03/07 | at | Texas | 8-1 |
| 09/04/07 | at | Texas | 8-9 |
| 09/05/07 | at | Texas | 2-3 |
| 09/07/07 | hosting | NY Yankees | 2-3 |
| 09/08/07 | hosting | NY Yankees | 5-11 |
| 09/09/07 | hosting | NY Yankees | 3-6 |
| 09/10/07 | hosting | Minnesota | 2-4 |
| 09/11/07 | hosting | Minnesota | 3-6 |
| 09/12/07 | hosting | Minnesota | 6-3 |
| 09/14/07 | at | Cleveland | 4-5 |
| 09/15/07 | at | Cleveland | 0-6 |
| 09/16/07 | at | Cleveland | 4-3 |
| 09/17/07 | hosting | Chi White Sox | 3-11 |
| 09/18/07 | hosting | Chi White Sox | 3-2 |
| 09/19/07 | hosting | Chi White Sox | 0-7 |
| 09/20/07 | hosting | Chi White Sox | 3-0 |
| 09/21/07 | at | Detroit | 4-5 |
| 09/22/07 | at | Detroit | 7-4 |
| 09/23/07 | at | Detroit | 2-7 |
| 09/24/07 | at | Baltimore | 2-3 |
| 09/25/07 | at | Chi White Sox | 9-5 |
| 09/26/07 | at | Chi White Sox | 0-3 |
| 09/27/07 | at | Chi White Sox | 0-10 |
| 09/28/07 | hosting | Cleveland | 3-5 |
| 09/29/07 | hosting | Cleveland | 4-3 |
| 09/30/07 | hosting | Cleveland | 2-4 |