| 04/02/07 | hosting | Tampa Bay | 9-5 |
| 04/05/07 | hosting | Tampa Bay | 6-7 |
| 04/06/07 | hosting | Baltimore | 4-6 |
| 04/07/07 | hosting | Baltimore | 10-7 |
| 04/08/07 | hosting | Baltimore | 4-6 |
| 04/09/07 | at | Minnesota | 8-2 |
| 04/10/07 | at | Minnesota | 10-1 |
| 04/11/07 | at | Minnesota | 1-5 |
| 04/13/07 | at | Oakland | 4-5 2OT |
| 04/14/07 | at | Oakland | 4-3 4OT |
| 04/15/07 | at | Oakland | 4-5 |
| 04/17/07 | hosting | Cleveland | 10-3 |
| 04/18/07 | hosting | Cleveland | 9-2 |
| 04/19/07 | hosting | Cleveland | 8-6 |
| 04/20/07 | at | Boston | 6-7 |
| 04/21/07 | at | Boston | 5-7 |
| 04/22/07 | at | Boston | 6-7 |
| 04/23/07 | at | Tampa Bay | 8-10 |
| 04/24/07 | at | Tampa Bay | 4-6 |
| 04/26/07 | hosting | Toronto | 0-6 |
| 04/27/07 | hosting | Boston | 4-11 |
| 04/28/07 | hosting | Boston | 3-1 |
| 04/29/07 | hosting | Boston | 4-7 |
| 05/01/07 | at | Texas | 10-1 |
| 05/03/07 | at | Texas | 4-3 |
| 05/03/07 | at | Texas | 5-2 |
| 05/04/07 | hosting | Seattle | 11-15 |
| 05/05/07 | hosting | Seattle | 8-1 |
| 05/06/07 | hosting | Seattle | 5-0 |
| 05/07/07 | hosting | Seattle | 2-3 |
| 05/08/07 | hosting | Texas | 8-2 |
| 05/09/07 | hosting | Texas | 6-2 |
| 05/10/07 | hosting | Texas | 2-14 |
| 05/11/07 | at | Seattle | 0-3 |
| 05/12/07 | at | Seattle | 7-2 |
| 05/13/07 | at | Seattle | 1-2 |
| 05/16/07 | at | Chi White Sox | 3-5 |
| 05/16/07 | at | Chi White Sox | 8-1 |
| 05/17/07 | at | Chi White Sox | 1-4 |
| 05/18/07 | at | NY Mets | 2-3 |
| 05/19/07 | at | NY Mets | 7-10 |
| 05/20/07 | at | NY Mets | 6-2 |
| 05/21/07 | hosting | Boston | 6-2 |
| 05/22/07 | hosting | Boston | 3-7 |
| 05/23/07 | hosting | Boston | 8-3 |
| 05/25/07 | hosting | Angels of Anaheim | 6-10 |
| 05/26/07 | hosting | Angels of Anaheim | 1-3 |
| 05/27/07 | hosting | Angels of Anaheim | 3-4 |
| 05/28/07 | at | Toronto | 2-7 |
| 05/29/07 | at | Toronto | 2-3 |
| 05/30/07 | at | Toronto | 10-5 |
| 06/01/07 | at | Boston | 9-5 |
| 06/02/07 | at | Boston | 6-11 |
| 06/03/07 | at | Boston | 6-5 |
| 06/04/07 | at | Chi White Sox | 4-6 |
| 06/05/07 | at | Chi White Sox | 7-3 |
| 06/06/07 | at | Chi White Sox | 5-1 |
| 06/07/07 | at | Chi White Sox | 10-3 |
| 06/08/07 | hosting | Pittsburgh | 5-4 OT |
| 06/09/07 | hosting | Pittsburgh | 9-3 |
| 06/10/07 | hosting | Pittsburgh | 13-6 |
| 06/12/07 | hosting | Arizona | 4-1 |
| 06/13/07 | hosting | Arizona | 7-2 |
| 06/14/07 | hosting | Arizona | 7-1 |
| 06/15/07 | hosting | NY Mets | 0-2 |
| 06/16/07 | hosting | NY Mets | 11-8 |
| 06/17/07 | hosting | NY Mets | 8-2 |
| 06/19/07 | at | Colorado | 1-3 |
| 06/20/07 | at | Colorado | 1-6 |
| 06/21/07 | at | Colorado | 3-4 |
| 06/22/07 | at | San Francisco | 7-3 |
| 06/23/07 | at | San Francisco | 5-6 4OT |
| 06/24/07 | at | San Francisco | 2-7 |
| 06/26/07 | at | Baltimore | 2-3 |
| 06/27/07 | at | Baltimore | 0-4 |
| 06/28/07 | at | Baltimore | 8-6 |
| 06/29/07 | hosting | Oakland | 2-1 |
| 06/30/07 | hosting | Oakland | 0-7 |
| 07/01/07 | hosting | Oakland | 5-11 |
| 07/02/07 | hosting | Minnesota | 5-1 |
| 07/03/07 | hosting | Minnesota | 8-0 |
| 07/04/07 | hosting | Minnesota | 2-6 |
| 07/05/07 | hosting | Minnesota | 7-6 |
| 07/06/07 | hosting | Angels of Anaheim | 14-9 |
| 07/07/07 | hosting | Angels of Anaheim | 1-2 4OT |
| 07/08/07 | hosting | Angels of Anaheim | 12-0 |
| 07/12/07 | at | Tampa Bay | 7-3 |
| 07/13/07 | at | Tampa Bay | 4-6 |
| 07/14/07 | at | Tampa Bay | 6-4 |
| 07/15/07 | at | Tampa Bay | 7-6 |
| 07/16/07 | hosting | Toronto | 6-4 |
| 07/17/07 | hosting | Toronto | 3-2 OT |
| 07/18/07 | hosting | Toronto | 6-1 |
| 07/19/07 | hosting | Toronto | 2-3 |
| 07/20/07 | hosting | Tampa Bay | 4-14 |
| 07/21/07 | hosting | Tampa Bay | 7-3 |
| 07/21/07 | hosting | Tampa Bay | 17-5 |
| 07/22/07 | hosting | Tampa Bay | 21-4 |
| 07/23/07 | at | Kansas City | 9-2 |
| 07/24/07 | at | Kansas City | 9-4 |
| 07/25/07 | at | Kansas City | 7-1 |
| 07/26/07 | at | Kansas City | 0-7 |
| 07/27/07 | at | Baltimore | 2-4 |
| 07/28/07 | at | Baltimore | 5-7 |
| 07/29/07 | at | Baltimore | 10-6 |
| 07/31/07 | hosting | Chi White Sox | 16-3 |
| 08/01/07 | hosting | Chi White Sox | 8-1 |
| 08/02/07 | hosting | Chi White Sox | 9-13 |
| 08/03/07 | hosting | Kansas City | 7-1 |
| 08/04/07 | hosting | Kansas City | 16-8 |
| 08/05/07 | hosting | Kansas City | 8-5 |
| 08/06/07 | at | Toronto | 5-4 |
| 08/07/07 | at | Toronto | 9-2 |
| 08/08/07 | at | Toronto | 4-15 |
| 08/10/07 | at | Cleveland | 6-1 |
| 08/11/07 | at | Cleveland | 11-2 |
| 08/12/07 | at | Cleveland | 5-3 |
| 08/13/07 | hosting | Baltimore | 7-6 |
| 08/14/07 | hosting | Baltimore | 0-12 |
| 08/15/07 | hosting | Baltimore | 3-6 OT |
| 08/16/07 | hosting | Detroit | 5-8 |
| 08/17/07 | hosting | Detroit | 6-1 |
| 08/18/07 | hosting | Detroit | 5-2 |
| 08/19/07 | hosting | Detroit | 9-3 |
| 08/20/07 | at | Angels of Anaheim | 6-7 OT |
| 08/21/07 | at | Angels of Anaheim | 9-18 |
| 08/22/07 | at | Angels of Anaheim | 8-2 |
| 08/24/07 | at | Detroit | 6-12 OT |
| 08/25/07 | at | Detroit | 7-2 |
| 08/26/07 | at | Detroit | 4-5 |
| 08/27/07 | at | Detroit | 0-16 |
| 08/28/07 | hosting | Boston | 5-3 |
| 08/29/07 | hosting | Boston | 4-3 |
| 08/30/07 | hosting | Boston | 5-0 |
| 08/31/07 | hosting | Tampa Bay | 1-9 |
| 09/01/07 | hosting | Tampa Bay | 9-6 |
| 09/02/07 | hosting | Tampa Bay | 2-8 |
| 09/03/07 | hosting | Seattle | 1-7 |
| 09/04/07 | hosting | Seattle | 12-3 |
| 09/05/07 | hosting | Seattle | 10-2 |
| 09/07/07 | at | Kansas City | 3-2 |
| 09/08/07 | at | Kansas City | 11-5 |
| 09/09/07 | at | Kansas City | 6-3 |
| 09/11/07 | at | Toronto | 9-2 |
| 09/12/07 | at | Toronto | 4-1 |
| 09/13/07 | at | Toronto | 1-2 |
| 09/14/07 | at | Boston | 8-7 |
| 09/15/07 | at | Boston | 1-10 |
| 09/16/07 | at | Boston | 4-3 |
| 09/17/07 | hosting | Baltimore | 8-5 |
| 09/18/07 | hosting | Baltimore | 12-0 |
| 09/19/07 | hosting | Baltimore | 2-1 |
| 09/21/07 | hosting | Toronto | 4-5 5OT |
| 09/22/07 | hosting | Toronto | 12-11 OT |
| 09/23/07 | hosting | Toronto | 7-5 |
| 09/24/07 | hosting | Toronto | 1-4 |
| 09/25/07 | at | Tampa Bay | 6-7 OT |
| 09/26/07 | at | Tampa Bay | 12-4 |
| 09/27/07 | at | Tampa Bay | 3-1 |
| 09/28/07 | at | Baltimore | 9-10 OT |
| 09/29/07 | at | Baltimore | 11-10 |
| 09/30/07 | at | Baltimore | 10-4 |
| 10/04/07 | at | Cleveland | 3-12 |
| 10/05/07 | at | Cleveland | 1-2 2OT |
| 10/07/07 | hosting | Cleveland | 8-4 |
| 10/08/07 | hosting | Cleveland | 4-6 |