| (49.72) | ||||
| 09/12/10 | at | Tampa Bay | (50.43) | 14-17 |
| 09/19/10 | hosting | Kansas City | (49.17) | 14-16 |
| 09/26/10 | at | Baltimore | (52.09) | 17-24 |
| 10/03/10 | hosting | Cincinnati | (49.08) | 23-20 |
| 10/10/10 | hosting | Atlanta | (51.16) | 10-20 |
| 10/17/10 | at | Pittsburgh | (52.04) | 10-28 |
| 10/24/10 | at | New Orleans | (50.44) | 30-17 |
| 11/07/10 | hosting | New England | (53.09) | 34-14 |
| 11/14/10 | hosting | N.Y. Jets | (52.17) | 20-26 OT |
| 11/21/10 | at | Jacksonville | (49.03) | 20-24 |
| 11/28/10 | hosting | Carolina | (46.97) | 24-23 |
| 12/05/10 | at | Miami | (50.16) | 13-10 |
| 12/12/10 | at | Buffalo | (49.47) | 6-13 |
| 12/19/10 | at | Cincinnati | (49.08) | 17-19 |
| 12/26/10 | hosting | Baltimore | (52.09) | 10-20 |
| 01/02/11 | hosting | Pittsburgh | (52.04) | 9-41 |