| (53.09) | ||||
| 09/12/10 | hosting | Cincinnati | (49.08) | 38-24 |
| 09/19/10 | at | N.Y. Jets | (52.17) | 14-28 |
| 09/26/10 | hosting | Buffalo | (49.47) | 38-30 |
| 10/04/10 | at | Miami | (50.16) | 41-14 |
| 10/17/10 | hosting | Baltimore | (52.09) | 23-20 OT |
| 10/24/10 | at | San Diego | (50.05) | 23-20 |
| 10/31/10 | hosting | Minnesota | (49.85) | 28-18 |
| 11/07/10 | at | Cleveland | (49.72) | 14-34 |
| 11/14/10 | at | Pittsburgh | (52.04) | 39-26 |
| 11/21/10 | hosting | Indianapolis | (50.01) | 31-28 |
| 11/25/10 | at | Detroit | (50.30) | 45-24 |
| 12/06/10 | hosting | N.Y. Jets | (52.17) | 45-3 |
| 12/12/10 | at | Chicago | (51.15) | 36-7 |
| 12/19/10 | hosting | Green Bay | (53.03) | 31-27 |
| 12/26/10 | at | Buffalo | (49.47) | 34-3 |
| 01/02/11 | hosting | Miami | (50.16) | 38-7 |
| 01/16/11 | hosting | N.Y. Jets | (52.17) | 21-28 |