| (50.30) | ||||
| 09/12/10 | at | Chicago | (51.15) | 14-19 |
| 09/19/10 | hosting | Philadelphia | (50.44) | 32-35 |
| 09/26/10 | at | Minnesota | (49.85) | 10-24 |
| 10/03/10 | at | Green Bay | (53.03) | 26-28 |
| 10/10/10 | hosting | St. Louis | (48.36) | 44-6 |
| 10/17/10 | at | N.Y. Giants | (50.24) | 20-28 |
| 10/31/10 | hosting | Washington | (49.05) | 37-25 |
| 11/07/10 | hosting | N.Y. Jets | (52.17) | 20-23 OT |
| 11/14/10 | at | Buffalo | (49.47) | 12-14 |
| 11/21/10 | at | Dallas | (49.84) | 19-35 |
| 11/25/10 | hosting | New England | (53.09) | 24-45 |
| 12/05/10 | hosting | Chicago | (51.15) | 20-24 |
| 12/12/10 | hosting | Green Bay | (53.03) | 7-3 |
| 12/19/10 | at | Tampa Bay | (50.43) | 23-20 OT |
| 12/26/10 | at | Miami | (50.16) | 34-27 |
| 01/02/11 | hosting | Minnesota | (49.85) | 20-13 |