| (50.05) | ||||
| 09/13/10 | at | Kansas City | (49.17) | 14-21 |
| 09/19/10 | hosting | Jacksonville | (49.03) | 38-13 |
| 09/26/10 | at | Seattle | (48.38) | 20-27 |
| 10/03/10 | hosting | Arizona | (47.31) | 41-10 |
| 10/10/10 | at | Oakland | (49.65) | 27-35 |
| 10/17/10 | at | St. Louis | (48.36) | 17-20 |
| 10/24/10 | hosting | New England | (53.09) | 20-23 |
| 10/31/10 | hosting | Tennessee | (48.98) | 33-25 |
| 11/07/10 | at | Houston | (49.03) | 29-23 |
| 11/22/10 | hosting | Denver | (47.62) | 35-14 |
| 11/28/10 | at | Indianapolis | (50.01) | 36-14 |
| 12/05/10 | hosting | Oakland | (49.65) | 13-28 |
| 12/12/10 | hosting | Kansas City | (49.17) | 31-0 |
| 12/16/10 | hosting | San Francisco | (48.64) | 34-7 |
| 12/26/10 | at | Cincinnati | (49.08) | 20-34 |
| 01/02/11 | at | Denver | (47.62) | 33-28 |