| (48.64) | ||||
| 09/12/10 | at | Seattle | (48.38) | 6-31 |
| 09/20/10 | hosting | New Orleans | (50.44) | 22-25 |
| 09/26/10 | at | Kansas City | (49.17) | 10-31 |
| 10/03/10 | at | Atlanta | (51.16) | 14-16 |
| 10/10/10 | hosting | Philadelphia | (50.44) | 24-27 |
| 10/17/10 | hosting | Oakland | (49.65) | 17-9 |
| 10/24/10 | at | Carolina | (46.97) | 20-23 |
| 10/31/10 | vs. | Denver | (47.62) | 24-16 |
| 11/14/10 | hosting | St. Louis | (48.36) | 23-20 OT |
| 11/21/10 | hosting | Tampa Bay | (50.43) | 0-21 |
| 11/29/10 | at | Arizona | (47.31) | 27-6 |
| 12/05/10 | at | Green Bay | (53.03) | 16-34 |
| 12/12/10 | hosting | Seattle | (48.38) | 40-21 |
| 12/16/10 | at | San Diego | (50.05) | 7-34 |
| 12/26/10 | at | St. Louis | (48.36) | 17-25 |
| 01/02/11 | hosting | Arizona | (47.31) | 38-7 |