| (49.65) | ||||
| 09/12/10 | at | Tennessee | (48.98) | 13-38 |
| 09/19/10 | hosting | St. Louis | (48.36) | 16-14 |
| 09/26/10 | at | Arizona | (47.31) | 23-24 |
| 10/03/10 | hosting | Houston | (49.03) | 24-31 |
| 10/10/10 | hosting | San Diego | (50.05) | 35-27 |
| 10/17/10 | at | San Francisco | (48.64) | 9-17 |
| 10/24/10 | at | Denver | (47.62) | 59-14 |
| 10/31/10 | hosting | Seattle | (48.38) | 33-3 |
| 11/07/10 | hosting | Kansas City | (49.17) | 23-20 OT |
| 11/21/10 | at | Pittsburgh | (52.04) | 3-35 |
| 11/28/10 | hosting | Miami | (50.16) | 17-33 |
| 12/05/10 | at | San Diego | (50.05) | 28-13 |
| 12/12/10 | at | Jacksonville | (49.03) | 31-38 |
| 12/19/10 | hosting | Denver | (47.62) | 39-23 |
| 12/26/10 | hosting | Indianapolis | (50.01) | 26-31 |
| 01/02/11 | at | Kansas City | (49.17) | 31-10 |