| (47.31) | ||||
| 09/12/10 | at | St. Louis | (48.36) | 17-13 |
| 09/19/10 | at | Atlanta | (51.16) | 7-41 |
| 09/26/10 | hosting | Oakland | (49.65) | 24-23 |
| 10/03/10 | at | San Diego | (50.05) | 10-41 |
| 10/10/10 | hosting | New Orleans | (50.44) | 30-20 |
| 10/24/10 | at | Seattle | (48.38) | 10-22 |
| 10/31/10 | hosting | Tampa Bay | (50.43) | 35-38 |
| 11/07/10 | at | Minnesota | (49.85) | 24-27 OT |
| 11/14/10 | hosting | Seattle | (48.38) | 18-36 |
| 11/21/10 | at | Kansas City | (49.17) | 13-31 |
| 11/29/10 | hosting | San Francisco | (48.64) | 6-27 |
| 12/05/10 | hosting | St. Louis | (48.36) | 6-19 |
| 12/12/10 | hosting | Denver | (47.62) | 43-13 |
| 12/19/10 | at | Carolina | (46.97) | 12-19 |
| 12/25/10 | hosting | Dallas | (49.84) | 27-26 |
| 01/02/11 | at | San Francisco | (48.64) | 7-38 |