| (48.98) | ||||
| 09/12/10 | hosting | Oakland | (49.65) | 38-13 |
| 09/19/10 | hosting | Pittsburgh | (52.04) | 11-19 |
| 09/26/10 | at | N.Y. Giants | (50.24) | 29-10 |
| 10/03/10 | hosting | Denver | (47.62) | 20-26 |
| 10/10/10 | at | Dallas | (49.84) | 34-27 |
| 10/18/10 | at | Jacksonville | (49.03) | 30-3 |
| 10/24/10 | hosting | Philadelphia | (50.44) | 37-19 |
| 10/31/10 | at | San Diego | (50.05) | 25-33 |
| 11/14/10 | at | Miami | (50.16) | 17-29 |
| 11/21/10 | hosting | Washington | (49.05) | 16-19 OT |
| 11/28/10 | at | Houston | (49.03) | 0-20 |
| 12/05/10 | hosting | Jacksonville | (49.03) | 6-17 |
| 12/09/10 | hosting | Indianapolis | (50.01) | 28-30 |
| 12/19/10 | hosting | Houston | (49.03) | 31-17 |
| 12/26/10 | at | Kansas City | (49.17) | 14-34 |
| 01/02/11 | at | Indianapolis | (50.01) | 20-23 |