| 10/07/05 | hosting | Wayne State | 1-1 OT |
| 10/08/05 | hosting | Wayne State | 2-1 |
| 10/14/05 | hosting | Minnesota | 0-2 |
| 10/15/05 | hosting | Minnesota | 2-3 |
| 10/21/05 | at | St. Cloud State | 2-6 |
| 10/22/05 | at | St. Cloud State | 1-4 |
| 11/04/05 | hosting | Minnesota State | 0-3 |
| 11/05/05 | hosting | Minnesota State | 2-1 |
| 11/11/05 | hosting | Mercyhurst | 2-2 OT |
| 11/12/05 | hosting | Mercyhurst | 2-4 |
| 11/18/05 | at | Minnesota-Duluth | 0-3 |
| 11/19/05 | at | Minnesota-Duluth | 1-5 |
| 11/25/05 | hosting | Ohio State | 2-4 |
| 11/26/05 | hosting | Ohio State | 5-2 |
| 12/03/05 | hosting | Wisconsin | 3-10 |
| 12/04/05 | hosting | Wisconsin | 1-4 |
| 12/10/05 | at | North Dakota | 0-4 |
| 12/11/05 | at | North Dakota | 6-1 |
| 12/30/05 | at | Cornell | 2-4 |
| 12/31/05 | at | Cornell | 1-2 |
| 01/06/06 | at | Minnesota | 2-7 |
| 01/07/06 | at | Minnesota | 2-1 |
| 01/13/06 | hosting | Minnesota-Duluth | 3-4 |
| 01/14/06 | hosting | Minnesota-Duluth | 3-4 |
| 01/20/06 | at | Minnesota State | 2-1 |
| 01/21/06 | at | Minnesota State | 2-5 |
| 01/28/06 | at | Wisconsin | 2-4 |
| 01/29/06 | at | Wisconsin | 1-3 |
| 02/03/06 | hosting | North Dakota | 5-4 OT |
| 02/04/06 | hosting | North Dakota | 1-0 |
| 02/10/06 | at | Ohio State | 2-1 |
| 02/11/06 | at | Ohio State | 5-4 |
| 02/24/06 | hosting | St. Cloud State | 5-1 |
| 02/25/06 | hosting | St. Cloud State | 0-4 |
| 03/03/06 | at | Minnesota-Duluth | 2-7 |
| 03/04/06 | at | Minnesota-Duluth | 0-3 |