| 09/04/05 | hosting | Virginia Tech | 16-20 |
| 09/17/05 | hosting | Eastern Kentucky | 54-10 |
| 09/24/05 | hosting | North Carolina | 24-31 |
| 10/06/05 | at | Georgia Tech | 17-14 |
| 10/13/05 | hosting | Clemson | 10-31 |
| 10/22/05 | at | Wake Forest | 19-27 |
| 10/29/05 | hosting | Southern Miss | 21-17 |
| 11/05/05 | at | Florida State | 20-15 |
| 11/12/05 | at | Boston College | 10-30 |
| 11/19/05 | hosting | Middle Tennessee State | 24-3 |
| 11/26/05 | hosting | Maryland | 20-14 |
| 12/31/05 | vs. | South Florida | 0.4804853035360865 |