| 09/03/05 | at | Pittsburgh | 42-21 |
| 09/10/05 | at | Michigan | 17-10 |
| 09/17/05 | hosting | Michigan State | 41-44 OT |
| 09/24/05 | at | Washington | 36-17 |
| 10/01/05 | at | Purdue | 49-28 |
| 10/15/05 | hosting | Southern Cal | 31-34 |
| 10/22/05 | hosting | Brigham Young | 49-23 |
| 11/05/05 | hosting | Tennessee | 41-21 |
| 11/12/05 | hosting | Navy | 42-21 |
| 11/19/05 | hosting | Syracuse | 34-10 |
| 11/26/05 | at | Stanford | 38-31 |
| 01/02/06 | vs. | Ohio State | 0.39506098283452984 |