| 09/03/05 | hosting | Miami OH | 34-14 |
| 09/10/05 | hosting | Texas | 22-25 |
| 09/17/05 | hosting | San Diego State | 27-6 |
| 09/24/05 | hosting | Iowa | 31-6 |
| 10/08/05 | at | Penn State | 10-17 |
| 10/15/05 | hosting | Michigan State | 35-24 |
| 10/22/05 | at | Indiana | 41-10 |
| 10/29/05 | at | Minnesota | 45-31 |
| 11/05/05 | hosting | Illinois | 40-2 |
| 11/12/05 | hosting | Northwestern | 48-7 |
| 11/19/05 | at | Michigan | 25-21 |
| 01/02/06 | vs. | Notre Dame | 0.6049390171654702 |