| 09/01/05 | at | Arizona State | 16-63 |
| 09/10/05 | at | Wisconsin | 0-65 |
| 09/17/05 | hosting | Toledo | 17-42 |
| 09/24/05 | hosting | Western Michigan | 16-19 |
| 10/01/05 | at | Bowling Green | 7-70 |
| 10/08/05 | hosting | Maryland | 7-38 |
| 10/15/05 | hosting | Miami FL | 3-34 |
| 10/22/05 | at | Clemson | 7-37 |
| 10/29/05 | hosting | Miami OH | 14-41 |
| 11/05/05 | at | Virginia | 3-51 |
| 11/19/05 | at | Navy | 17-38 |