| 09/02/06 | hosting | Akron | 34-16 |
| 09/09/06 | at | Notre Dame | 17-41 |
| 09/16/06 | hosting | Youngstown St | 37-3 |
| 09/23/06 | at | Ohio State | 6-28 |
| 09/30/06 | hosting | Northwestern | 33-7 |
| 10/07/06 | at | Minnesota | 28-27 OT |
| 10/14/06 | hosting | Michigan | 10-17 |
| 10/21/06 | hosting | Illinois | 26-12 |
| 10/28/06 | at | Purdue | 12-0 |
| 11/04/06 | at | Wisconsin | 3-13 |
| 11/11/06 | hosting | Temple | 47-0 |
| 11/18/06 | hosting | Michigan St | 17-13 |
| 01/01/07 | at | Tennessee | 20-10 |