| 09/03/05 | hosting | Guilford | 41-7 |
| 09/10/05 | at | Emory & Henry | 29-13 |
| 09/17/05 | at | Chowan | 43-26 |
| 09/24/05 | at | Shenandoah | 34-13 |
| 10/01/05 | hosting | Averett | 55-40 |
| 10/08/05 | at | Maryville | 56-34 |
| 10/14/05 | hosting | Methodist | 42-37 |
| 10/29/05 | hosting | Greensboro | 55-0 |
| 11/05/05 | at | North Carolina Wesleyan | 63-28 |
| 11/12/05 | hosting | Christopher Newport | 7-44 |
| 11/19/05 | at | Wesley | 14-59 |