| 08/27/05 | at | Lane | 24-6 |
| 09/03/05 | hosting | Shaw | 33-0 |
| 09/10/05 | at | Mars Hill | 13-6 |
| 09/17/05 | hosting | Virginia St | 44-14 |
| 09/24/05 | vs. | Elizabeth City St | 7-0 |
| 10/01/05 | at | North Carolina Central | 22-8 |
| 10/08/05 | hosting | Johnson C. Smith | 26-7 |
| 10/15/05 | at | Livingstone | 20-14 |
| 10/22/05 | hosting | Fayetteville St | 28-45 |
| 10/29/05 | at | Winston-Salem St | 33-35 |