| 09/02/06 | hosting | Appalachian St | 23-10 |
| 09/09/06 | hosting | Akron | 17-20 |
| 09/16/06 | at | Southern Miss | 17-37 |
| 09/23/06 | hosting | Boston College | 17-15 |
| 10/05/06 | hosting | Florida St | 24-20 |
| 10/14/06 | hosting | Wake Forest | 23-25 |
| 10/21/06 | at | Maryland | 20-26 |
| 10/28/06 | at | Virginia | 7-14 |
| 11/04/06 | hosting | Georgia Tech | 23-31 |
| 11/11/06 | at | Clemson | 14-20 |
| 11/18/06 | at | North Carolina | 9-23 |
| 11/25/06 | hosting | East Carolina | 16-21 |