| 09/02/06 | at | Pittsburgh | 13-38 |
| 09/09/06 | hosting | Wyoming | 13-12 OT |
| 09/16/06 | hosting | Western Michigan | 10-17 |
| 09/21/06 | at | Georgia Tech | 7-24 |
| 09/30/06 | at | Duke | 37-0 |
| 10/07/06 | at | East Carolina | 21-31 |
| 10/14/06 | hosting | Maryland | 26-28 |
| 10/19/06 | hosting | North Carolina | 23-0 |
| 10/28/06 | hosting | North Carolina St | 14-7 |
| 11/04/06 | at | Florida St | 0-33 |
| 11/18/06 | hosting | Miami FL | 17-7 |
| 11/25/06 | at | Virginia Tech | 0-17 |