| 11/01/05 | at | Philadelphia | 117-108 OT |
| 11/02/05 | at | New Jersey | 110-96 |
| 11/05/05 | hosting | Miami | 105-100 |
| 11/08/05 | hosting | Golden State | 103-110 |
| 11/12/05 | hosting | Indiana | 103-102 |
| 11/15/05 | at | L.A. Clippers | 85-109 |
| 11/16/05 | at | Golden State | 90-87 |
| 11/18/05 | at | Sacramento | 82-103 |
| 11/21/05 | at | Utah | 80-100 |
| 11/23/05 | hosting | Philadelphia | 108-97 |
| 11/25/05 | at | Minnesota | 91-99 |
| 11/26/05 | hosting | Detroit | 76-85 |
| 11/29/05 | hosting | Dallas | 113-111 OT |
| 12/02/05 | at | Washington | 105-102 |
| 12/03/05 | hosting | Orlando | 104-84 |
| 12/06/05 | hosting | L.A. Lakers | 92-111 |
| 12/07/05 | at | Philadelphia | 88-85 |
| 12/10/05 | hosting | Cleveland | 111-106 |
| 12/12/05 | at | New York | 112-92 |
| 12/14/05 | hosting | Miami | 83-100 |
| 12/16/05 | at | Boston | 100-96 |
| 12/17/05 | hosting | Utah | 80-88 |
| 12/20/05 | hosting | San Antonio | 109-107 OT |
| 12/23/05 | hosting | New Orleans/Okla Cty | 101-94 |
| 12/26/05 | at | Orlando | 93-108 |
| 12/27/05 | at | Miami | 98-109 |
| 12/30/05 | hosting | New York | 113-108 |
| 01/02/06 | at | Chicago | 93-92 |
| 01/04/06 | hosting | Cleveland | 84-91 |
| 01/06/06 | hosting | Chicago | 91-105 |
| 01/07/06 | at | Cleveland | 88-96 |
| 01/10/06 | hosting | Minnesota | 95-92 |
| 01/11/06 | at | Indiana | 88-112 |
| 01/13/06 | at | Charlotte | 103-102 |
| 01/14/06 | hosting | Denver | 93-100 |
| 01/16/06 | at | Dallas | 95-114 |
| 01/18/06 | at | San Antonio | 92-95 |
| 01/20/06 | at | Atlanta | 118-102 |
| 01/21/06 | hosting | Charlotte | 101-91 |
| 01/23/06 | hosting | Houston | 80-97 |
| 01/25/06 | at | Detroit | 102-106 OT |
| 01/27/06 | hosting | Toronto | 108-87 |
| 01/29/06 | hosting | Boston | 83-79 |
| 01/30/06 | at | New Orleans/Okla Cty | 93-94 |
| 02/01/06 | at | Houston | 84-86 |
| 02/04/06 | hosting | Memphis | 88-78 |
| 02/06/06 | at | Cleveland | 86-89 |
| 02/08/06 | hosting | Orlando | 94-89 2OT |
| 02/11/06 | hosting | Charlotte | 99-93 |
| 02/12/06 | at | New Jersey | 79-94 |
| 02/14/06 | hosting | Seattle | 106-91 |
| 02/15/06 | at | Indiana | 77-88 |
| 02/21/06 | hosting | New Jersey | 85-89 |
| 02/22/06 | at | Chicago | 91-97 |
| 02/24/06 | hosting | Philadelphia | 111-116 |
| 02/25/06 | at | Atlanta | 99-89 |
| 02/27/06 | at | Denver | 110-89 |
| 03/01/06 | at | Phoenix | 110-123 |
| 03/04/06 | hosting | New York | 98-103 |
| 03/08/06 | hosting | Sacramento | 116-123 |
| 03/10/06 | at | Boston | 92-86 |
| 03/11/06 | hosting | L.A. Clippers | 98-106 |
| 03/13/06 | hosting | Atlanta | 88-87 |
| 03/15/06 | hosting | Chicago | 104-88 |
| 03/17/06 | at | Toronto | 96-97 |
| 03/18/06 | hosting | Portland | 97-93 |
| 03/20/06 | at | Portland | 100-93 |
| 03/22/06 | at | Seattle | 105-114 |
| 03/24/06 | at | L.A. Lakers | 96-101 |
| 03/26/06 | hosting | Toronto | 125-116 OT |
| 03/28/06 | hosting | Phoenix | 132-110 |
| 03/31/06 | at | Detroit | 105-112 |
| 04/01/06 | hosting | Indiana | 96-89 |
| 04/04/06 | at | Miami | 89-115 |
| 04/05/06 | at | Orlando | 105-108 |
| 04/07/06 | at | Memphis | 90-100 |
| 04/09/06 | hosting | New Jersey | 83-95 |
| 04/12/06 | hosting | Washington | 100-97 |
| 04/14/06 | at | New York | 97-80 |
| 04/15/06 | hosting | Atlanta | 114-120 |
| 04/17/06 | hosting | Detroit | 113-93 |
| 04/18/06 | at | Washington | 103-116 |
| 04/23/06 | at | Detroit | 74-92 |
| 04/26/06 | at | Detroit | 98-109 |
| 04/29/06 | hosting | Detroit | 124-104 |
| 05/01/06 | hosting | Detroit | 99-109 |
| 05/03/06 | at | Detroit | 93-122 |