| 09/03/05 | vs. | South Carolina St | 14-27 |
| 09/10/05 | at | Texas Southern | 27-15 |
| 09/17/05 | at | Arkansas-Pine Bluff | 41-10 |
| 09/24/05 | hosting | Alcorn St | 38-3 |
| 10/01/05 | vs. | Southern U. | 45-35 |
| 10/08/05 | at | Jackson State | 44-23 |
| 10/15/05 | hosting | Prairie View A&M | 34-13 |
| 10/29/05 | vs. | Alabama A&M | 28-31 |
| 11/05/05 | hosting | Grambling State | 27-32 |
| 11/12/05 | at | Mississippi Valley St | 33-38 |
| 11/24/05 | hosting | Tuskegee | 27-28 |