| 11/13/05 | vs. | NC Wilmington | 59-75 |
| 11/14/05 | vs. | Alabama St. | 70-61 |
| 11/15/05 | vs. | Lehigh | 66-41 |
| 11/22/05 | at | Ohio St. | 69-79 OT |
| 11/26/05 | at | Michigan | 74-78 |
| 11/30/05 | hosting | Tulane | 82-61 |
| 12/03/05 | at | Ball St. | 64-53 |
| 12/06/05 | hosting | Bradley | 70-60 |
| 12/17/05 | hosting | Indiana St. | 58-59 |
| 12/19/05 | hosting | Elon | 86-40 |
| 12/23/05 | vs. | Indiana | 55-73 |
| 12/28/05 | at | South Dakota St. | 85-48 |
| 01/02/06 | hosting | Illinois Chicago | 75-56 |
| 01/07/06 | at | Wisconsin Milwaukee | 59-64 |
| 01/14/06 | hosting | Detroit | 64-52 |
| 01/19/06 | at | Loyola Chicago | 64-74 |
| 01/21/06 | at | Youngstown St. | 62-64 |
| 01/25/06 | at | Cleveland St. | 55-51 |
| 01/28/06 | hosting | Wright St. | 70-62 |
| 01/30/06 | at | Illinois Chicago | 67-39 |
| 02/02/06 | hosting | Wisconsin Green Bay | 72-66 OT |
| 02/04/06 | hosting | Wisconsin Milwaukee | 63-60 OT |
| 02/08/06 | hosting | Cleveland St. | 78-49 |
| 02/11/06 | at | Wright St. | 83-86 2OT |
| 02/13/06 | at | Wisconsin Green Bay | 63-57 |
| 02/16/06 | hosting | Loyola Chicago | 62-50 |
| 02/18/06 | at | Kent St. | 76-80 OT |
| 02/22/06 | hosting | Youngstown St. | 72-64 |
| 02/25/06 | at | Detroit | 71-73 |
| 03/04/06 | vs. | Wisconsin Green Bay | 73-51 |
| 03/07/06 | at | Wisconsin Milwaukee | 71-87 |
| 03/14/06 | hosting | Miami OH | 53-52 |
| 03/17/06 | at | Florida St. | 63-67 |