| 10/07/05 | vs. | Air Force | 3-1 |
| 10/08/05 | at | Colorado College | 2-3 OT |
| 10/14/05 | hosting | Denver | 5-1 |
| 10/15/05 | hosting | Denver | 4-2 |
| 10/21/05 | hosting | Alabama-Huntsville | 3-1 |
| 10/22/05 | hosting | Alabama-Huntsville | 4-0 |
| 10/28/05 | at | Boston College | 2-1 |
| 10/29/05 | at | Massachusetts | 4-0 |
| 11/04/05 | hosting | Merrimack | 3-1 |
| 11/06/05 | hosting | Boston University | 1-2 |
| 11/11/05 | at | Mass.-Lowell | 9-2 |
| 11/12/05 | at | New Hampshire | 2-4 |
| 11/27/05 | hosting | Vermont | 1-2 |
| 12/02/05 | at | Providence | 2-4 |
| 12/07/05 | hosting | Brown | 2-1 |
| 12/10/05 | hosting | Northeastern | 5-2 |
| 12/27/05 | vs. | Minnesota-Duluth | 1-4 |
| 12/28/05 | vs. | Northeastern | 4-2 |
| 01/06/06 | hosting | Mass.-Lowell | 4-0 |
| 01/07/06 | hosting | Mass.-Lowell | 6-2 |
| 01/13/06 | at | Boston University | 2-3 |
| 01/14/06 | at | Boston University | 4-5 |
| 01/20/06 | hosting | Providence | 0-4 |
| 01/21/06 | hosting | Providence | 5-2 |
| 01/27/06 | at | Northeastern | 6-3 |
| 01/28/06 | at | Northeastern | 2-1 |
| 02/03/06 | hosting | New Hampshire | 4-1 |
| 02/04/06 | hosting | New Hampshire | 4-7 |
| 02/10/06 | at | Vermont | 3-1 |
| 02/11/06 | at | Vermont | 4-4 OT |
| 02/17/06 | hosting | Boston College | 4-1 |
| 02/18/06 | hosting | Boston College | 3-1 |
| 02/24/06 | at | Merrimack | 4-1 |
| 02/25/06 | at | Merrimack | 2-1 |
| 03/03/06 | hosting | Massachusetts | 2-2 OT |
| 03/04/06 | hosting | Massachusetts | 5-3 |
| 03/10/06 | hosting | Mass.-Lowell | 4-3 OT |
| 03/11/06 | hosting | Mass.-Lowell | 4-3 |
| 03/17/06 | vs. | Boston College | 1-4 |
| 03/25/06 | vs. | Harvard | 6-1 |
| 03/26/06 | vs. | Michigan State | 5-4 |
| 04/06/06 | vs. | Wisconsin | 2-5 |