| 10/08/05 | vs. | Wayne State | 5-1 |
| 10/09/05 | vs. | North Dakota | 3-0 |
| 10/22/05 | at | Michigan | 3-3 OT |
| 10/28/05 | at | Cornell | 2-4 |
| 10/29/05 | at | Cornell | 4-3 |
| 11/04/05 | hosting | Northern Michigan | 5-4 OT |
| 11/05/05 | hosting | Northern Michigan | 5-0 |
| 11/08/05 | at | Ferris State | 2-2 OT |
| 11/11/05 | hosting | Nebraska-Omaha | 4-7 |
| 11/12/05 | hosting | Nebraska-Omaha | 2-3 OT |
| 11/15/05 | at | Ohio State | 2-3 |
| 11/18/05 | hosting | Western Michigan | 3-3 OT |
| 11/19/05 | at | Western Michigan | 3-5 |
| 11/25/05 | hosting | Wisconsin | 1-3 |
| 11/26/05 | hosting | Minnesota | 2-2 OT |
| 12/02/05 | hosting | Bowling Green | 3-0 |
| 12/03/05 | at | Bowling Green | 2-4 |
| 12/09/05 | at | Alaska-Fairbanks | 4-4 OT |
| 12/10/05 | at | Alaska-Fairbanks | 3-0 |
| 12/29/05 | vs. | Michigan Tech | 3-2 OT |
| 12/30/05 | vs. | Colorado College | 3-6 |
| 01/06/06 | hosting | Wayne State | 3-1 |
| 01/07/06 | hosting | Wayne State | 5-1 |
| 01/13/06 | hosting | Alaska-Fairbanks | 4-0 |
| 01/14/06 | hosting | Alaska-Fairbanks | 2-1 |
| 01/17/06 | hosting | Michigan | 2-0 |
| 01/20/06 | at | Nebraska-Omaha | 4-3 OT |
| 01/21/06 | at | Nebraska-Omaha | 2-3 |
| 01/24/06 | hosting | Ferris State | 1-2 |
| 01/27/06 | hosting | Michigan | 1-1 OT |
| 01/28/06 | vs. | Michigan | 5-5 OT |
| 02/03/06 | at | Notre Dame | 3-2 |
| 02/04/06 | hosting | Notre Dame | 2-1 |
| 02/09/06 | at | Ohio State | 4-3 |
| 02/17/06 | hosting | Miami | 3-2 |
| 02/18/06 | hosting | Miami | 3-1 |
| 02/23/06 | at | Lake Superior | 3-2 |
| 02/25/06 | at | Lake Superior | 2-2 OT |
| 03/10/06 | hosting | Alaska-Fairbanks | 1-2 |
| 03/11/06 | hosting | Alaska-Fairbanks | 6-1 |
| 03/12/06 | hosting | Alaska-Fairbanks | 7-4 |
| 03/17/06 | vs. | Michigan | 4-1 |
| 03/18/06 | vs. | Miami | 2-1 |
| 03/25/06 | vs. | New Hampshire | 1-0 |
| 03/26/06 | vs. | Maine | 4-5 |