| (48.04) | ||||
| 09/07/08 | at | Tennessee | (52.47) | 10-17 |
| 09/14/08 | hosting | Buffalo | (48.28) | 16-20 |
| 09/21/08 | at | Indianapolis | (52.44) | 23-21 |
| 09/28/08 | hosting | Houston | (50.33) | 30-27 OT |
| 10/05/08 | hosting | Pittsburgh | (52.96) | 21-26 |
| 10/12/08 | at | Denver | (48.23) | 24-17 |
| 10/26/08 | hosting | Cleveland | (48.19) | 17-23 |
| 11/02/08 | at | Cincinnati | (49.17) | 19-21 |
| 11/09/08 | at | Detroit | (43.82) | 38-14 |
| 11/16/08 | hosting | Tennessee | (52.47) | 14-24 |
| 11/23/08 | hosting | Minnesota | (50.68) | 12-30 |
| 12/01/08 | at | Houston | (50.33) | 17-30 |
| 12/07/08 | at | Chicago | (49.86) | 10-23 |
| 12/14/08 | hosting | Green Bay | (49.42) | 20-16 |
| 12/18/08 | hosting | Indianapolis | (52.44) | 24-31 |
| 12/28/08 | at | Baltimore | (53.80) | 7-27 |