| (49.17) | ||||
| 09/07/08 | at | Baltimore | (53.80) | 10-17 |
| 09/14/08 | hosting | Tennessee | (52.47) | 7-24 |
| 09/21/08 | at | N.Y. Giants | (52.60) | 23-26 OT |
| 09/28/08 | hosting | Cleveland | (48.19) | 12-20 |
| 10/05/08 | at | Dallas | (50.99) | 22-31 |
| 10/12/08 | at | N.Y. Jets | (49.13) | 14-26 |
| 10/19/08 | hosting | Pittsburgh | (52.96) | 10-38 |
| 10/26/08 | at | Houston | (50.33) | 6-35 |
| 11/02/08 | hosting | Jacksonville | (48.04) | 21-19 |
| 11/16/08 | hosting | Philadelphia | (52.53) | 13-13 OT |
| 11/20/08 | at | Pittsburgh | (52.96) | 10-27 |
| 11/30/08 | hosting | Baltimore | (53.80) | 3-34 |
| 12/07/08 | at | Indianapolis | (52.44) | 3-35 |
| 12/14/08 | hosting | Washington | (49.68) | 20-13 |
| 12/21/08 | at | Cleveland | (48.19) | 14-0 |
| 12/28/08 | hosting | Kansas City | (46.39) | 16-6 |