| (49.68) | ||||
| 09/04/08 | at | N.Y. Giants | (52.60) | 7-16 |
| 09/14/08 | hosting | New Orleans | (50.31) | 29-24 |
| 09/21/08 | hosting | Arizona | (49.98) | 24-17 |
| 09/28/08 | at | Dallas | (50.99) | 26-24 |
| 10/05/08 | at | Philadelphia | (52.53) | 23-17 |
| 10/12/08 | hosting | St. Louis | (46.17) | 17-19 |
| 10/19/08 | hosting | Cleveland | (48.19) | 14-11 |
| 10/26/08 | at | Detroit | (43.82) | 25-17 |
| 11/03/08 | hosting | Pittsburgh | (52.96) | 6-23 |
| 11/16/08 | hosting | Dallas | (50.99) | 10-14 |
| 11/23/08 | at | Seattle | (48.05) | 20-17 |
| 11/30/08 | hosting | N.Y. Giants | (52.60) | 7-23 |
| 12/07/08 | at | Baltimore | (53.80) | 10-24 |
| 12/14/08 | at | Cincinnati | (49.17) | 13-20 |
| 12/21/08 | hosting | Philadelphia | (52.53) | 10-3 |
| 12/28/08 | at | San Francisco | (48.63) | 24-27 |