| 09/03/05 | at | Iowa | 0-56 |
| 09/10/05 | hosting | Bowling Green | 31-40 |
| 09/17/05 | at | Auburn | 3-63 |
| 10/01/05 | at | Boston College | 0-38 |
| 10/08/05 | at | Western Michigan | 60-57 5OT |
| 10/15/05 | hosting | Toledo | 14-34 |
| 10/22/05 | at | Ohio U. | 21-38 |
| 10/29/05 | at | Northern Illinois | 31-17 |
| 11/05/05 | hosting | Akron | 23-17 |
| 11/12/05 | at | Eastern Michigan | 26-25 |
| 11/19/05 | hosting | Central Michigan | 24-31 OT |