| 09/03/05 | at | Northwestern | 14-38 |
| 09/09/05 | hosting | Pittsburgh | 16-10 OT |
| 09/17/05 | at | Virginia Tech | 0-45 |
| 09/24/05 | hosting | Kent St | 35-32 |
| 10/08/05 | at | Bowling Green | 14-38 |
| 10/15/05 | at | Central Michigan | 10-37 |
| 10/22/05 | hosting | Ball State | 38-21 |
| 10/29/05 | at | Buffalo | 34-20 |
| 11/04/05 | hosting | Toledo | 21-30 |
| 11/15/05 | at | Akron | 3-27 |
| 11/21/05 | hosting | Miami OH | 7-38 |