| 09/03/05 | at | Michigan State | 14-49 |
| 09/10/05 | hosting | SE Missouri St | 33-12 |
| 09/17/05 | hosting | Miami OH | 10-27 |
| 09/24/05 | at | Ohio U. | 32-35 |
| 10/01/05 | at | Eastern Michigan | 20-27 |
| 10/15/05 | at | Navy | 31-34 |
| 10/22/05 | hosting | Northern Illinois | 3-34 |
| 10/29/05 | at | Western Michigan | 14-44 |
| 11/05/05 | hosting | Bowling Green | 14-24 |
| 11/12/05 | hosting | Buffalo | 6-10 |
| 11/24/05 | at | Akron | 3-35 |