| 09/10/05 | at | Purdue | 24-49 |
| 09/17/05 | at | Middle Tennessee State | 17-7 |
| 09/24/05 | hosting | Northern Illinois | 48-42 OT |
| 10/01/05 | hosting | Central Michigan | 17-31 |
| 10/08/05 | at | Buffalo | 13-7 |
| 10/15/05 | at | Miami OH | 23-51 |
| 10/22/05 | hosting | Army | 0-20 |
| 10/29/05 | at | Bowling Green | 24-14 |
| 11/05/05 | at | Ball State | 17-23 |
| 11/15/05 | hosting | Ohio U. | 27-3 |
| 11/24/05 | hosting | Kent St | 35-3 |
| 12/01/05 | vs. | Northern Illinois | 31-30 |
| 12/26/05 | vs. | Memphis | 31-38 |