| 09/04/05 | at | North Carolina State | 20-16 |
| 09/10/05 | at | Duke | 45-0 |
| 09/17/05 | hosting | Ohio U. | 45-0 |
| 09/24/05 | hosting | Georgia Tech | 51-7 |
| 10/01/05 | at | West Virginia | 34-17 |
| 10/08/05 | hosting | Marshall | 41-14 |
| 10/20/05 | at | Maryland | 28-9 |
| 10/27/05 | hosting | Boston College | 30-10 |
| 11/05/05 | hosting | Miami FL | 7-27 |
| 11/19/05 | at | Virginia | 52-14 |
| 11/26/05 | hosting | North Carolina | 30-3 |
| 12/03/05 | vs. | Florida State | 22-27 |
| 01/02/06 | vs. | Louisville | 0.5985409525889107 |