| 09/03/05 | hosting | Hiram | 45-0 |
| 09/10/05 | at | Grove City | 20-16 |
| 09/17/05 | hosting | Johns Hopkins | 6-9 |
| 09/24/05 | at | Franklin & Marshall | 0-6 |
| 10/01/05 | at | Colorado College | 63-28 |
| 10/15/05 | at | Chicago | 6-35 |
| 10/22/05 | hosting | Washington U. | 7-28 |
| 10/29/05 | hosting | Case Western Reserve | 23-20 |
| 11/05/05 | at | Bethany WV | 30-15 |
| 11/12/05 | hosting | Thiel | 48-50 |