| 09/03/05 | hosting | Franklin & Marshall | 34-21 |
| 09/10/05 | hosting | Thomas More | 15-33 |
| 09/17/05 | at | Defiance | 26-29 |
| 09/24/05 | at | Thiel | 7-41 |
| 10/01/05 | at | Grove City | 12-21 |
| 10/08/05 | hosting | Waynesburg | 21-38 |
| 10/15/05 | hosting | Westminster PA | 13-34 |
| 10/22/05 | at | Wash & Jeff | 0-63 |
| 10/29/05 | hosting | Chicago | 3-42 |
| 11/05/05 | hosting | Carnegie Mellon | 15-30 |