| 09/03/05 | at | Manchester | 21-24 |
| 09/10/05 | hosting | Carnegie Mellon | 16-20 |
| 09/17/05 | at | Thomas More | 7-15 |
| 09/24/05 | hosting | Muhlenberg | 16-6 |
| 10/01/05 | hosting | Bethany WV | 21-12 |
| 10/08/05 | at | Thiel | 0-30 |
| 10/15/05 | hosting | Wash & Jeff | 14-37 |
| 10/22/05 | hosting | Waynesburg | 7-6 |
| 10/29/05 | at | Alfred | 7-27 |
| 11/05/05 | at | Westminster PA | 13-14 |