| 09/03/05 | at | Tri-State | 42-0 |
| 09/10/05 | hosting | Hanover | 56-20 |
| 09/17/05 | hosting | Allegheny | 45-21 |
| 09/24/05 | at | Emory & Henry | 50-0 |
| 10/01/05 | hosting | Thiel | 35-38 |
| 10/08/05 | at | Westminster PA | 45-20 |
| 10/15/05 | at | Grove City | 37-14 |
| 10/22/05 | hosting | Bethany WV | 63-0 |
| 10/29/05 | at | Waynesburg | 35-24 |
| 11/05/05 | at | Thomas More | 32-14 |
| 11/19/05 | at | Bridgewater VA | 21-30 |