| 09/10/05 | hosting | Ohio Wesleyan | 39-36 |
| 09/17/05 | at | Bluffton | 42-0 |
| 09/24/05 | hosting | Bethany WV | 41-7 |
| 10/01/05 | at | Wash & Jeff | 38-35 |
| 10/08/05 | hosting | Grove City | 30-0 |
| 10/15/05 | at | Waynesburg | 35-28 |
| 10/22/05 | at | Westminster PA | 34-0 |
| 10/29/05 | hosting | Thomas More | 24-14 |
| 11/05/05 | hosting | Buffalo St | 21-3 |
| 11/12/05 | at | Carnegie Mellon | 50-48 |
| 11/19/05 | hosting | Johns Hopkins | 28-3 |
| 11/26/05 | hosting | Bridgewater VA | 13-24 |