| 09/03/05 | at | Arkansas | 17-49 |
| 09/10/05 | hosting | Quincy | 51-14 |
| 09/17/05 | hosting | SE Missouri St | 45-21 |
| 10/01/05 | at | Southern Illinois | 23-30 |
| 10/08/05 | hosting | Northern Iowa | 24-21 |
| 10/15/05 | at | Western Kentucky | 28-37 |
| 10/22/05 | at | Youngstown St | 7-31 |
| 10/29/05 | hosting | Indiana State | 31-27 |
| 11/05/05 | hosting | Illinois St | 23-48 |
| 11/12/05 | at | Western Illinois | 24-34 |