| 09/01/05 | at | SE Missouri St | 58-23 |
| 09/10/05 | hosting | Union KY | 82-7 |
| 09/17/05 | at | Western Michigan | 28-34 |
| 10/01/05 | hosting | Missouri St | 30-23 |
| 10/08/05 | at | Western Illinois | 34-24 |
| 10/15/05 | hosting | Illinois St | 35-61 |
| 10/22/05 | at | Indiana State | 42-20 |
| 10/27/05 | at | Western Kentucky | 31-20 |
| 11/05/05 | hosting | Youngstown St | 31-17 |
| 11/12/05 | at | Northern Iowa | 24-25 |
| 11/19/05 | hosting | North Dakota St | 9-0 |
| 11/26/05 | at | Eastern Illinois | 21-6 |
| 12/03/05 | at | Appalachian State | 24-38 |