| 09/01/05 | hosting | Eastern Illinois | 13-24 |
| 09/10/05 | hosting | St Francis IN | 10-42 |
| 09/17/05 | at | Murray State | 15-27 |
| 09/24/05 | at | Texas Tech | 7-63 |
| 10/01/05 | hosting | Western Kentucky | 28-38 |
| 10/08/05 | hosting | Youngstown St | 0-45 |
| 10/15/05 | at | Northern Iowa | 10-31 |
| 10/22/05 | hosting | Southern Illinois | 20-42 |
| 10/29/05 | at | Missouri St | 27-31 |
| 11/05/05 | hosting | Western Illinois | 35-63 |
| 11/12/05 | at | Illinois St | 28-70 |