| 09/10/05 | at | Indiana State | 42-10 |
| 09/17/05 | hosting | McKendree | 28-21 |
| 09/24/05 | hosting | UW-Eau Claire | 35-10 |
| 10/01/05 | hosting | Geneva | 50-22 |
| 10/08/05 | at | Ohio Dominican | 49-7 |
| 10/15/05 | at | Urbana | 35-3 |
| 10/22/05 | hosting | Taylor | 55-0 |
| 10/29/05 | at | Malone | 28-7 |
| 11/05/05 | hosting | Quincy | 53-19 |
| 11/12/05 | at | Walsh | 21-7 |
| 11/19/05 | hosting | Pikeville | 41-7 |
| 11/26/05 | hosting | Georgetown KY | 44-14 |
| 12/03/05 | hosting | Morningside | 42-14 |