| 09/03/05 | at | Illinois | 30-33 |
| 09/10/05 | hosting | Villanova | 38-6 |
| 09/17/05 | at | Buffalo | 17-3 |
| 09/30/05 | hosting | Pittsburgh | 37-29 |
| 10/08/05 | hosting | West Virginia | 14-27 |
| 10/15/05 | at | Syracuse | 31-9 |
| 10/22/05 | at | Connecticut | 26-24 |
| 10/29/05 | hosting | Navy | 31-21 |
| 11/05/05 | hosting | South Florida | 31-45 |
| 11/11/05 | at | Louisville | 5-56 |
| 11/26/05 | hosting | Cincinnati | 44-9 |
| 12/27/05 | vs. | Arizona State | 0.3412886060914321 |