| 11/18/05 | hosting | North Dakota St. | 70-57 |
| 11/26/05 | hosting | Chattanooga | 67-46 |
| 11/28/05 | hosting | Gardner Webb | 72-73 |
| 11/30/05 | at | Maryland | 66-83 |
| 12/03/05 | hosting | Coastal Carolina | 75-57 |
| 12/05/05 | at | Arizona St. | 85-79 OT |
| 12/10/05 | hosting | Nevada Las Vegas | 72-67 |
| 12/14/05 | hosting | UAB | 69-68 |
| 12/21/05 | hosting | Grambling | 88-64 |
| 12/23/05 | hosting | South Dakota St. | 80-61 |
| 12/31/05 | hosting | Oral Roberts | 67-54 |
| 01/07/06 | hosting | Northwestern | 49-57 |
| 01/10/06 | hosting | Wisconsin | 62-64 |
| 01/14/06 | at | Purdue | 55-72 |
| 01/18/06 | at | Iowa | 72-76 3OT |
| 01/21/06 | hosting | Michigan | 55-71 |
| 01/25/06 | at | Illinois | 53-77 |
| 01/29/06 | hosting | Indiana | 61-42 |
| 02/04/06 | at | Ohio St. | 53-67 |
| 02/08/06 | at | Penn St. | 77-66 |
| 02/11/06 | hosting | Michigan St. | 69-55 |
| 02/15/06 | at | Michigan | 50-72 |
| 02/18/06 | hosting | Iowa | 74-61 |
| 02/22/06 | hosting | Purdue | 62-50 |
| 02/26/06 | at | Wisconsin | 74-80 |
| 02/28/06 | hosting | Illinois | 65-71 |
| 03/04/06 | at | Northwestern | 53-57 |
| 03/09/06 | vs. | Michigan | 59-55 |
| 03/10/06 | vs. | Iowa | 57-67 |
| 03/15/06 | hosting | Wake Forest | 73-58 |
| 03/21/06 | at | Cincinnati | 62-76 |