| 09/02/06 | at | North Carolina | 21-16 |
| 09/09/06 | hosting | Illinois | 33-0 |
| 09/16/06 | hosting | Ohio U. | 24-7 |
| 09/23/06 | hosting | Howard | 56-7 |
| 09/29/06 | at | South Florida | 22-20 |
| 10/14/06 | at | Navy | 34-0 |
| 10/21/06 | at | Pittsburgh | 20-10 |
| 10/29/06 | hosting | Connecticut | 24-13 |
| 11/09/06 | hosting | Louisville | 28-25 |
| 11/18/06 | at | Cincinnati | 11-30 |
| 11/25/06 | hosting | Syracuse | 38-7 |
| 12/02/06 | at | West Virginia | 39-41 OT |
| 12/28/06 | at | Kansas St | 37-10 |